Introduce

I'm Aleksei TikhonovPh.D. in Molecular Biology and Oncology

Postdoctoral Fellowship in Translational Cancer Immunotherapy

Rounded Text

10+

Years of
Experience

15+

publications in
peer-review journails

2

patients

50+

oral and poster presentations
at international conferences

About

I am committed to contributing to advancing cancer research and technology development to improve patient outcomes.

A visionary and accomplished professional with over 10 years of experience in translational and clinical cancer immunotherapy, biomarker discovery, and precision medicine. 

- Designed and reviewed 5+ phase I-III clinical trials and prepared regulatory documents for medical device registration.

- Led and executed translational research projects on novel assays and biomarkers for cancer diagnosis and treatment, resulting in 10 publications and 2 patents.

- Fostered and led high-performing teams, accelerated the strategy, and built effective stakeholder relationships both in academia and industry. 

- Actively participated in scientific associations and societies advocating for DEI, health equity, and patient care.

With a diversified background in academia, industry, and non-profits, I am interested in applying my skills and focusing on translational research, clinical development, and medical support of novel drugs and innovative technologies.

resume

Work Experience

March 2022 - September 2023, Villejuif, France

Postdoctoral Research Scientist

Gustave Roussy, Translational Research Laboratory in Immunotherapy

Supervisor: Dr. Aurélien Marabelle

- Led and conducted a translational research project on B-cell and antibody responses to immunotherapy in cancer patients
- Worked on the PREMIS trial and evaluated biomarkers associated with immune-related adverse events in NSCLC patients receiving immune checkpoint inhibitors
- Collaborated with multidisciplinary teams to design and implement translational programs in innovative phase I-III immunotherapy clinical trials
- Participated in the development and evaluation of clinical trial protocols and related documents
- Conducted experiments and interpreted data using multiplex ELISA (Meso Scale Discovery/HuProt) and flow-cytometry (BD LSRFortessa) platforms to profile cell lines, tumors, and immune cells
- Mentored junior researchers and helped them improve their skills and productivity
- Wrote scientific papers, grant applications, and clinical reports; disseminated the results

July 2021 - September 2022, Moscow, Russia

Lead Technical Writer, Communications Lead

Lumiprobe

- Performed market analysis and participated in launching more than 20 innovative products on the worldwide market that met customer needs and expectations
- Developed and executed a global social media strategy that increased brand awareness and engagement
- Led and coordinated cross-functional team of writers, editors, designers, and reviewers to deliver high-quality content on time, promoting collaboration and communication
- Created compelling and logically structured content for the website that highlighted the features and benefits of the products and provided clear guidance for customers
- Spearheaded the development and implementation of internal instructions and protocols for the synthesis/use of products that complied with quality requirements, ensuring safety and reliability
- Managed multiple projects simultaneously, tracked milestones, and resolved any challenges or conflicts

February 2022 - August 2022, Moscow, Russia

Independent Consultant

Nanolek

- Evaluated the scientific and commercial potential of novel drug candidates and technologies
- Provided strategic recommendations and guidance on the best opportunities for investment and partnership
- Conducted market research and analysis to identify promising targets for drug development in oncology and immunology

August 2014 - December 2021, Moscow, Russia

Graduate Research Scientist

Engelhardt Institute of Molecular Biology, Laboratory of Biological Microchips

- Developed and initiated a multicenter diagnostic clinical trial for minimally-invasive early diagnosis of colorectal cancer
- Designed and implemented 2 phase II Immuno-Oncology clinical trials (NCT04739566 and NCT04731740) in anaplastic thyroid cancer
- Initiated translational biomarkers research programs in laboratory ongoing projects
- Prepared non-clinical and clinical regulatory documents for marketing authorization of medical devices in Russia and Kazakhstan, developed by our laboratory spin-off company «BIOCHIP-IMB». Documents for two kits for cancer and allergy diagnosis are now under consideration
- Developed and implemented 3D-hydrogel protein and glycan microarray assays that detected cancer-associated proteins and glycan-specific antibodies with >80% sensitivity and specificity
- Identified natural anti-glycan antibody repertoires in sera of more than 600 colorectal and ovarian cancer patients using various techniques, revealing novel insights into the immune response to cancer
- Characterized exosome subpopulations specific for colorectal cancer, uncovering new molecular signatures of cancer progression
- Worked in a multidisciplinary team and contributed to 8 joint publications and 2 patents, demonstrating effective collaboration and communication skills
- Demonstrated excellent problem-solving skills by troubleshooting technical issues, optimizing experimental protocols, validating results, ensuring the quality and reliability of the data

March 2020 - September 2020, Moscow, Russia

Data Analyst

BostonGene

- Developed and maintained a comprehensive database of circulating cancer biomarkers for the USA and Europe
- Established and updated a proprietary company's platform of signaling pathways in lung cancer, providing a valuable resource for researchers and clinicians within the company
- Performed advanced data analysis of genomic, transcriptomic, and proteomic biomarkers using internal company tools
- Contributed to the expansion of the knowledge base on targeted- and immuno-therapies, identifying novel biomarkers and drug candidates
- Prepared reports for physicians, summarizing the latest evidence on biomarkers and therapies for lung cancer

October 2011 - February 2014, Moscow, Russia

Research Scientist

Institute of Biomedical Chemistry
, Laboratory of Systems Biology

– Prepared samples and performed mass spectrometry analysis using MALDI-TOF and Q-TO
– Analyzed mass spectrometry data using Masco
– Identified and annotated proteins encoded by human chromosome 18

October 2005 - March 2009, Moscow, Russia

Research Scientist

Zelinsky Institute of Organic Chemistry,
 Laboratory of Fine Organic Synthesis

– Developed a new methodology of one-pot synthesis of various substituted styreneX
– Used ionic liquids as green solvent
– Characterized products with NMR, IR, GC-MS, and HPLC method
– Published and presented results in peer-reviewed journals and conferences

Education

Education

Mar 2022 - Sep 2023, Paris, France

Postdoctoral Fellowship, Translational Cancer Immunotherapy

Gustave Roussy

2015 - 2021, Moscow, Russia

Ph.D. in Molecular Biology and Oncology

Engelhardt Institute of Molecular Biology

2006 - 2015, Moscow, Russia

Specialist diploma in Chemistry (equivalent to B.Sc.+M.Sc.)

Higher Chemical College at the Russian Academy of Sciences

Services

Technical Skills

Clinical trials design and writing

NCT04739566 and NCT04731740

2 clinical trials

Clinical trials (phases I-III) management and data analysis

NCT03984318, NCT03838263, NCT02856425 and NCT02857569

4 clinical trials

Clinical trials and medical devices regulatory compliance

Preparation of regulatory documents for marketing authorization of ELISA kits for cancer and allergy diagnosis in the Eurasian Economic Union.

Statistical skills

Statistics, figure design, and scientific data analysis

Figma

MedCalc

Figma

SPSS

Figma

GraphPad Prism

Figma

R

Multicolor flow cytometry and cell sorting

T- and B-cell subsets analysis using BD LSRFortessa, FlowJo, and Kaluza

Automated immunoassay analysis

MSD Meso Scale Discovery and Luminex platforms

Live cell imaging and cytotoxicity assays

Agilent xCELLigence

Proteins and antibodies

Extraction, purification, multiplex ELISA, 1D and 2D electrophoresis, western- blot, fluorescent labeling, immunostaining, E. coli inclusion bodies extraction

Microarray assays

Design, fabrication, quality control, and implementation of DNA, proteins/antibodies and glycan microarrays, scanning and data analysis (GenePix)

Confocal and fluorescence microscopy

HPLC and affinity chromatography, mass spectrometry (LC-MS including ESI and MALDI)

Bruker and Agilent platforms

MUSIC OF CELLS | Documentary about cancer

What you need to know about cancer? Detailed information about modern oncology.

Young Forum Gastein Interview: Antonella Cardone

As we approach World Cancer Day, this week’s #YFG2021 interview sees Young Gasteiners Sarah Moundir, EU Public Affairs Junior Manager, Novartis and Aleksei Tikhonov, Research scientist, Engelhardt Institute of Molecular Biology speak with Antonella Cardone Director, European Cancer Patient Organisation about the Europe's Beating Cancer Plan and the effects of COVID-19 on cancer care.

honors and awards

Honors and awards

September 2023

SITC Sparkathon Class of 2023

Selected as one of 12 emerging leaders in cancer immunotherapy for a highly competitive program that aims to address the challenges of toxicities in cancer immunotherapy

May 2022

EFLM Laboratory Exchange Programme (EFLMLabX) Bursary

April 2022

French Society of Clinical Biology (SFBC) Grant

November 2019, Seoul, Korea

AACR - KCA Young Investigator Scholarship

AACR-KCA Joint Workshop on Precision Medicine in Cancer

September 2019, Heidelberg, Germany

EMBL Corporate Partnership Programme Travel Grant and Registration fee waiver

EMBL Course Liquid Biopsies (selected oral presentation)

September 2019, Luso, Portugal

FEBS Youth Travel Fund (YTF) Grant

2nd FEBS Advanced Lecture Course on Oncometabolism (selected oral presentation)

January 2019, Brussels, Belgium

ESMO Translational Research Unit Visit (TRU) Fellowship

Competitive fellowship to visit the Breast Cancer Translational Research Laboratory at Institut Jules Bordet

October 2018, Algarve, Portugal

CCE - EACR Fellowship

Summer School in Translational Cancer Research (selected oral presentation)

October 2017

Edina Trust Grant

Grant named “Andrei Mirzabekov Travel Grant Scheme” via a gift aid donation from Professor Sir E.M. Southern

January 2017 - December 2017

Russian Federation Government Scholarship

Highly competitive one-year scholarship

November 2015

Winner of the young scientists contest at the XIX Russian Oncological Congress

Professional service

Professional service

February 2021 - Present

Early Career Scientist Committee Member

Society for Immunotherapy of Cancer (SITC)

– Organized and moderated 3 networking events for 50+ early career scientists in 2021-2022
– Pioneered the first Speed Mentoring Event at SITC 37th Annual Meeting with 100% positive feedback
– Recruited and matched 20+ cancer immunotherapy leaders with 40+ mentees

March 2020 - Present

Communication Committee Member and Task Group Young Scientists Member

European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

– Created engaging website and social media content
– Led EFLM rebranding strategy
– Co-founded Task Group Young Scientists
– Maintained effective communication within the Federation and with stakeholders

August 2022 - Present

Diversity, Equity, & Inclusion (DE&I) Steering Committee Member and Tumor Marker and Cancer Diagnostics Division (TMCD) Communications Officer

Association for Diagnostics & Laboratory Medicine (ADLM)

– Applied DEI principles to all ADLM policies and programs
– Enhanced leadership, engagement, and advancement for underrepresented ADLM members
– Advocated for DEI in the laboratory medicine profession
– Supported health equity and access to improve patient care and outcomes

January 2021 - Present

Global Policy Committee Member

European Society for Medical Oncology (ESMO)

– Contributed to projects on cancer prevention, control, workforce, and services
– Participated in ESMO’s policy efforts to advance medical oncology
– Promoted better cancer care and research globally

Certifications

Certifications

August 2023

GATE-X-LS: Lead & Invest In Life Sciences From Lab To IPO

Online Course

August 2023

ICH E6(R1): Guideline for Good Clinical Practice E6(R2)

Gustave Roussy

November 2022

GSAS Harvard Biotech Club and Morrison Foerster Fall Patent Law

Virtual Course

2021

Young Forum Gastein (YFG) alumni

European Health Forum Gastein

2020

Local Pathways Fellow

UN Sustainable Development Solutions Network – Youth

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